Month: December 2025

JAKARTA, Dec 15, 2025 - (ACN Newswire via SeaPRwire.com) - Indonesia's state-owned railway operator PT Kereta Api Indonesia (KAI) has rolled out two major initiatives aimed at strengthening national mobility and accelerating its digital shift: the launch of the Farmer and Trader Train on the Merak Commuter Line, and the expansion of face recognition boarding technology ahead of the 2025/2026 Christmas and New Year travel season.Farmer-Trader train to facilitate the movement of agricultural goods, processed food, and small-scale merchandise by providing dedicated cargo space within a commuter railway environment.KAI said the programs reflect its commitment to inclusive transport services while enhancing operational efficiency and environmental performance — moves that align with international railway modernization trends.A special passenger train featuring oversized windows and often a large glass roof (sunroof) to provide unobstructed, wide-angle views of the passing scenery, turning the journey itself into a scenic experience."KAI is committed to building a rail ecosystem that supports grassroots economies while adopting technologies that meet global service standards," said KAI President Director Bobby Rasyidin. "These initiatives reinforce railways as an inclusive, efficient, and sustainable mode of public transport."New Farmer–Trader Train Strengthens Local Product DistributionEffective 1 December 2025, KAI began operating the Farmer and Trader Train on the Merak–Rangkasbitung corridor in Banten Province. The service is designed to facilitate the movement of agricultural goods, processed food, and small-scale merchandise by providing dedicated cargo space within a commuter railway environment.The rolling stock was fully redesigned by Balai Yasa Surabaya Gubeng, KAI's technical workshop, which modified the interior layout, baggage sections, loading–unloading access points, and safety signage to meet the needs of micro and small enterprises."The train has been engineered by our in-house experts to ensure safe, orderly, and convenient goods movement without disrupting passenger flow," continued Rasyidin.The service operates under a government-funded Public Service Obligation (PSO) scheme with a flat fare of Rp3,000, allowing up to two cargo units per user. It is attached to 14 daily Commuter Line services and stops at 11 stations across coastal and agricultural areas.On launch day, 95 customers used the service, carrying agricultural produce, snacks, and handicrafts for markets in Serang, Cilegon, and Merak. KAI expects the service to reduce traders' reliance on road-based logistics and shift more local supply chains onto rail.Rasyidin said the initiative strengthens regional economic resilience: "Reliable logistics access for small producers is fundamental to local economies. This service opens a more predictable distribution channel for farmers and traders."Facial Recognition Technology Boosts Efficiency, Cuts WasteKAI is also expanding its facial recognition boarding system to improve passenger processing and reduce paper usage in major stations.KAI VP Public Relations Anne Purba, explains, between January and October 2025, the feature recorded 9.29 million uses, cutting ticket paper consumption by 23,245 rolls, equivalent to Rp341 million in savings. Since the system debuted in 2023, it has been used by 19.4 million passengers, contributing significantly to KAI's environmental and cost-reduction goals."Facial recognition shortens boarding time and significantly reduces paper waste, supporting more environmentally responsible operations," Purba said.The technology is now available in 22 stations, with wider deployment planned ahead of peak holiday travel to reduce queues and streamline passenger flow.Purba underscored the strategic value of automation: "Digitalization is not just innovation—it is increasingly essential to managing national mobility at scale. This system helps maintain operational stability when travel demand peaks."Holiday Ticket Sales Climb, Discounts ExpandedDemand for the year-end holiday period—18 December 2025 to 4 January 2026—continues to rise. As of 26 November, KAI had sold 629,060 tickets, or 21.15% of the roughly 3 million seats available.To support affordability and smooth travel, KAI is offering 30% discounts for 156 regular services and 26 additional economy-class trains, totaling 1.5 million discounted seats valid from 22 December to 10 January.Purba said higher mobility is expected across Java and Sumatra: "We are preparing large capacity and fare incentives to ensure safe, orderly, and accessible travel throughout the holiday season."Inclusive and Technology-Driven Mobility for IndonesiaBy combining inclusive rural-focused services with large-scale digital transformation, KAI aims to bring Indonesia's rail sector closer to global standards of accessibility, efficiency, and sustainability."Our strategy aligns with international efforts to build modern public transport systems that deliver broad social and economic impact," Purba concluded.For More Information, please contact:Anne PurbaVP Public RelationsPT Kereta Api Indonesia (Persero)Source: PT Kereta Api Indonesia (Persero), https://www.kai.id Copyright 2025 ACN Newswire via SeaPRwire.com. All rights reserved. www.acnnewswire.com

香港, 2025年12月15日 - (亚太商讯 via SeaPRwire.com) - 12月12日，华芢生物-B(02396.HK)正式开启招股，公司拟全球发售1764.88万股股份，其中香港发售股份176.50万股，国际发售股份1588.38万股，附带264.72万股超额配股权，招股期至12月17日，最高发售价51.00港元，中国生物制药领域也将迎来重磅IPO。据悉，华芢生物深耕伤口愈合领域，在糖尿病足（糖足）领域取得突破性进展，精准卡位老龄化及糖尿病年轻化万亿级刚需市场。依托青岛高科（崂山区财政局全资控股的国资平台）的产业资源整合能力与政策协同优势，叠加自主搭建的"蛋白+核酸"双技术平台及覆盖14个适应症的差异化管线布局，以及行业顶尖高管团队加持，为港股市场投资者构筑起抵御18A生物科技企业高风险的安全边际。市场普遍将其视为继宝济药业之后又一具备高成长潜力的港股18A标的——不仅拥有扎实的临床进展和清晰的商业化路径，更兼具稀缺性与确定性，有望成为下一个被资本市场深度挖掘的价值明星。银发浪潮叠加年轻化趋势：糖足治疗刚需市场再扩容据国家统计局数据，全国60周岁及以上人口达3.1亿（占总人口22.0%），其中65岁以上人群占比突破15.6%。老龄化加速催生糖尿病防控压力，而与此同时，糖尿病年轻化趋势正进一步扩大患者基数，形成"银发群体为主、青年群体补充"的双重市场增量。弗若斯特沙利文报告显示，我国糖尿病患者约1.4亿，四分之一的糖尿病患者会在某个阶段发展为糖足，2024年中国的糖足患病人数为840万人。而当前GLP-1类减肥药（如司美格鲁肽）因减重效果显著成为"网红神药"，但其作用机制聚焦于抑制食欲与延缓胃排空，对糖足等血管神经病变类并发症无实质改善。与此同时，术后伤口愈合市场规模同样超千亿，传统治疗手段痛点显著。在糖足治疗领域，已从传统外科清创转向生物制剂主导的精准修复时代。中国糖足患者基数庞大，传统疗法（清创+抗生素）因无法解决血管神经病变导致的慢性创面修复障碍，临床愈合率长期低于50%。PDGF（血小板衍生生长因子）类药物凭借其独特的"血管新生-组织修复"双效机制，能够特异性激活特定受体，促进成纤维细胞增殖与毛细血管生成，显著加速创面愈合进程，成为千亿级慢病管理与术后修复赛道的重磅增长引擎。华芢生物正是瞄准这一蓝海市场，向"港股PDGF第一股"发起冲击。技术突破+医保减负：核心产品创造多重价值即便处于高研发投入期，华芢生物仍通过自主研发实现关键突破——优化核心技术序列并革新生产工艺，构建起差异化竞争优势。其核心产品Pro-101-1的IIa期数据显示，可使浅/深二度烧伤愈合时间缩短约7天，较传统疗法效率提升25%，这一突破为患者、医疗体系与医保基金创造多重价值。对糖足及烧伤患者而言，愈合时间缩短能直接减少住院时长与家庭护理成本，降低因术后恢复导致的误工、护理人员误工等间接经济损失，堪称"糖尿病足患者的福音"；对医疗体系来说，患者住院周期缩短可提高病床周转率，减少医疗资源占用，缓解医护人员工作压力；对医保基金而言，治疗周期缩短与再治疗需求降低，能有效减轻医保支出负担，契合当前医疗保障体系降本增效的核心诉求。从技术平台来看，华芢生物以自主搭建的蛋白质药物技术平台为核心，形成"蛋白+核酸"双轮创新架构：酵母表达系统通过工艺革新提升蛋白生产效率，双引擎协同支撑烧伤修复、糖尿病足溃疡、脱发治疗等核心产品的临床转化，同时展现出向肿瘤疫苗、罕见病领域延展的技术潜力，为长期发展奠定技术基础。国资托底+高管赋能+顶尖平台+强力护航：四重保障化解研发与市场风险生物制药的研发向来充满不确定性，一款新药从实验室到上市往往九死一生。但在华芢生物这里，这种风险似乎被巧妙地拆解成了可控变量。在股权与资源端，青岛高科产业发展有限公司（崂山区财政局全资控股的国资平台）作为核心股东，通过持股17.32%（全球发售后相关类别股份）形成长期绑定，其国资属性为公司在地方医疗资源对接、政策协调中奠定信任基础，成为连接区域产业生态与研发管线的关键纽带。在管理端，公司获MNC大厂高管赋能，迎来两位行业顶尖人才加盟，进一步强化创新发展底气。其中，苗天祥先生曾是"外资药企中国掌门人"代表，拥有近30年辉瑞中国工作经历，曾任辉瑞中国大中华区主席，在财务、企业管理及制药行业积累深厚经验，现任华芢生物执行董事兼首席战略官，负责制定、实施和监督公司整体战略规划，为企业把握行业方向、推进研发与市场布局提供关键指导；宋冰女士曾长期任职于顶尖国际投行高盛高华证券，担任总经理兼首席运营官，在金融投资、企业战略及资本运作领域具备极强创造力与领导力，现任公司监事会主席，为整体规划提供建议与监督，助力优化资源整合、提升资本运作效率。两位核心高管的"组合赋能"，与研发团队技术创新形成合力，让华芢生物在PDGF药物研发与市场拓展中具备独特优势。在资本端，本次IPO由中信证券担任联席保荐人。值得一提的是，中信证券2025年在港股18A生物科技IPO领域表现亮眼，其保荐的其中7个项目均实现首日未破发，映恩生物、劲方医药等项目首日涨幅超100%，12月10日挂牌的宝济药业更录得3526.34倍公开发售认购、暗盘一度暴涨超115%的佳绩，中慧生物、旺山旺水也分别创下4007.64倍、6238.42倍的超高认购，充分获得机构及专业投资者认可，为后续二级市场投资者提供坚实信心支撑。在管线端，公司"阶梯式"研发管线进一步降低风险。目前，用于治疗深二度烧烫伤的产品Pro-101-1，已完成IIb期临床试验的统计数据分析，用于治疗浅二度烧烫伤的，已完成最后一例患者出组；用于治疗糖尿病足溃疡（糖足）的产品Pro-101-2正处于II期临床试验阶段。未来，PDGF也有望应用于普通外科、牙科、皮肤科等近20个适应症。就连看似"跨界"的脱发微针产品Pro-104，也已规划在2029年提交IND申请。这种"成熟产品贡献现金流、在研管线储备未来"的布局，像极了跨国药企的经典打法——即便某一管线受挫，也不至于动摇根基。稀缺标的+港股通预期：投资者的优质选择从市场属性来看，华芢生物是"小而美"的稀缺标的，当前发行规模适中，流通盘较小，叠加清晰的盈利路径与高壁垒技术平台，使其具备极强的流动性溢价潜力。市场普遍预期其在满足市值与流动性条件后有望快速纳入港股通，吸引南向资金配置，进一步放大赚钱效应。尽管近期港股市场有6支新股同步发售，资金面承压，但华芢生物凭借其纯正的18A生物科技属性，明确的临床里程碑及国资背景与高管优势，在年末IPO窗口中脱颖而出。对投资者而言，"国资背书+技术平台+管线梯队+高管赋能"的组合，让风险更可量化，契合长期资本对确定性增长的需求。在老龄化加速与创新药政策红利共振下，华芢生物以"愈合刚需+技术壁垒+国资护航+高管赋能"构建起独特价值坐标。对于寻求确定性增长的长期资本而言，这家即将登陆港交所的生物制药新星，或将成为对冲行业波动、捕捉结构性机会的优质标的。其扎实技术与管线积淀更将为港股创新药板块注入新动能，推动PDGF药物行业创新升级，专业投资市场亦在期待其更长期的价值兑现。 Copyright 2025 亚太商讯 via SeaPRwire.com. All rights reserved. www.acnnewswire.com

TransNusa Launched 11 International Routes in 3 YearsIndonesia-based PT TransNusa Mandiri Aviation grows a strong brand with expansion focusing on international routesTransNusa focuses on international tourism island destinations to offer domestic and foreign tourists increased air connectivityTransNusa introduces four new domestic scheduled direct flights to boost connectivity from Bali to Lombok and Bima as well as between renowned diving destinations Manado to Sorong and Sorong to Timika, world’s largest gold mining islandJAKARTA, Dec 15, 2025 - (ACN Newswire via SeaPRwire.com) - TransNusa has successfully launched four new domestic routes today, securing 19 routes in total within three years of operations.TransNusa Group CEO, aviation veteran, Datuk Bernard Francis, known for his acute, unique and out-of-the-box turnaround and change management strategies, led TransNusa towards a secure yet bold growth pattern using a customized business model, which was specifically developed to suit the changing market demand after the onslaught of the pandemic.“What we envisioned for TransNusa was to build an Indonesian-based airline with strong fundamentals. Today, thanks to our hard working and diligent team, the TransNusa brand has grown to resonates confidence and trust,” said Datuk Bernard, adding that TransNusa’s shareholder, China Aircraft Leasing Group Holdings Limited (CALC) and business partners also played a large role in helping build TransNusa into the strong brand it is today.Within 6 months of its operations, TransNusa launched its first international route between Jakarta and Kuala Lumpur, followed by three additional international routes in that same year, including Singapore and China.TransNusa also implemented a milestones as well as initiated and developed new domestic routes, such as the Bali-Manado route.In addition, TransNusa the first Indonesian airline to operate regular scheduled international flights into Guanzhou from three destinations in Indonesia.Datuk Bernard said the primary factor in the successful growth of TransNusa, in the last three years, was their goal to implement a lasting and impactful change around not just the organisation and its people but also its business model and operations.“In TransNusa, a 100% change is not possible overnight, whereas a 5% change in a moderate manner is not only more feasible but allows for a lasting change,” said Datuk Bernard, explaining that it was that principal which has been the backbone of TransNusa's operations and growth.On the new domestic route launches, Datuk Bernard said that TransNusa hopes to provide increased connectivity and travelling options to domestic and international tourists.“We would like to play our part in boosting and increasing air connectivity within Indonesia’s internationally renowned tourism island destinations.“Our focus is in increasing direct flight to destinations that are world renowned for its unique and stunning landscape and natural offerings,” said Datuk Bernard.DATUK BERNARD FRANCIS… TransNusa's team and business partners contributed to the growth of the airline and it’s brand.Flight DetailsTransNusa’s flight from Bali to Lombok will operate two times daily beginning Monday, December 15. The TransNusa flight will depart Bali from the Denpasar International Airport at 07.30am and arrive in Lombok International Airport at 07.55am, with the return flight departing Lombok at 08.25am and arriving in Bali at 09.05am. The second TransNusa flight will depart Bali at 15.55pm and arrive in Lombok at 16.50pm, with the return flight departing Lombok at 17.20pm and arriving in Bali at 18.05pm.“We will increase the frequency of the scheduled flights for the Bali-Lombok route to three times daily on December 21.” Said Datuk Bernard.The third scheduled flight will depart Bali at 18.55pm and arrive at Lombok at 19.35pm. The scheduled flight from Lombok will depart at 20.00pm and arrive in Bali at 20.25pm.Meanwhile, TransNusa’s flight from Bali to Bima will also begin on Monday, December 15.“For the first week, we will operate one scheduled flight from Bali to Bima on Monday, Wednesday, Friday and Sunday.“Starting December 22, TransNusa will operate daily scheduled flights from Bali to Bima,” said Datuk Bernard, adding that the flight will depart Bali from the Denpasar International Airport at 09.35am and arrive at 10.35am at the Sultan Muhammad Salahuddin Airport in Bima.The return flight will depart Bima’s Sultan Muhammad Salahuddin Airport at 11.00am and arrive at Bali’s Denpasar International Airport at 12.10pm.Meanwhile, TransNusa’s schedule flight from Sorong to Timika will operate four times weekly on Monday, Tuesday, Thursday and Saturday.The flight, which will also begin on December 15, will depart Sorong from the Domine Eduard Osok International Airport at 10.50am and arrive in Timika’s Mozes Kilangin Airport at 12.10pm. The return flight will depart Timika at 12.40pm and arrive in Sorong at 14.00pm.On the much sought-after Manado-Sorong route, Datuk Bernard said that TransNusa’s will operate its scheduled flight from Manado to Sorong four times weekly.The scheduled flight from diving haven Manado will operate on Monday, Tuesday, Thursday and Saturday. The flight will depart Manado’s Sam Ratulangi International AIrport at 08.00am and arrive in Sorong’s Domine Eduard Osok International Airport at 10.20am. The return flight will depart Sorong at 14.30pm and arrive in Manado at 14.50pm.TransNusa, A Short HistoryThe 3-year old TransNusa, led by aviation expert and veteran, Datuk Bernard, made waves in the aviation industry with its unique domestic and international business development and growth strategy.Within just 6 months of operations, in 2023, the airline, known then as a new player with new rules, launched its first international route between Jakarta and Kuala Lumpur, followed by the launch of scheduled flights between Jakarta and Singapore.TransNusa, which established itself as a Premium Service Carrier, made headlines in Malaysia, Singapore, China and around the world with news of being the first airline in Indonesia to introduce new exciting routes. In 2023, during its first year of operations, TransNusa became the second Indonesian airline to receive approval to fly to China. In 2024, TransNusa became the first in the world to develop and introduce a new domestic route connecting Bali and Manado. In October 2025, TransNusa added yet another milestones by becoming the first Indonesian airline and second airline in the world to launch scheduled flights from Manado to Guangzhou, China.Media Contact:Trina Thomas RajMobile: +6012 4992672E-mail: trina@myqaseh.org Copyright 2025 ACN Newswire via SeaPRwire.com. All rights reserved. www.acnnewswire.com