Month: December 2025

TOKYO, Dec 3, 2025 - (JCN Newswire via SeaPRwire.com) - Anime Tokyo Station is an anime exhibition site focused on Japanese anime content, which has developed a devout fan base around the world. From November 15, 2025 to February 15, 2026, it will be holding the “Digimon Adventure 02” & “Magical DoReMi #” ANIME 25TH ANNIVERSARY JOINT EXHIBITION. A sneak preview was held for the press on November 14, the day before the exhibition opened.Visitors to the anniversary joint exhibition can enjoy a variety of unique displays at Anime Tokyo Station, including rare character design materials, interactive digital content, and photo spots.Please visit Anime Tokyo Station and experience the full appeal of Digimon Adventure 02 and Magical DoReMi #.Exhibits ”Digimon Adventure 02” ＆ “Magical DoReMi #” ANIME 25TH ANNIVERSARY JOINT EXHIBITIONWhat is “Digimon Adventure 02”?Digimon Adventure 02 is the second series in the franchise, serving as a sequel to Digimon Adventure, which depicted the growth and adventures of children and their Digimon partners in the Digital World.Set three years after Taichi and friends’ adventure, a new enemy appears in the now-peaceful Digital World. A new-generation Digimon, V-MON, and his partner Daisuke Motomiya, along with returning heroes Hikari Yagami and Takeru Takaishi and new allies Iori Hida and Miyako Inoue, face the crisis threatening the Digital World. The series features a diverse array of evolution methods, including Armor Evolution and Jogress Evolution, in addition to standard evolution, adding to its appeal.DIGIMONWEB https://digimon.net/ Digimon Web Official X @digimonweb_net Digimon Anime Series [Official] X @Digimon_Anime Anime DIGIMON BEATBREAK Official X @digimon_tv What is the “Magical DoReMi” Series?The Magical DoReMi series were broadcast on Japanese television for four years, starting in 1999, celebrating the 25th anniversary of its broadcast in 2024.The story follows three girls, Doremi, Hazuki, and Aiko, who accidentally end up becoming witch apprentices. Set between their school and a shop called “MAHO-DO,” the series depicts their magical, miraculous daily training to become full-fledged witches. Throughout the series, charming characters such as Onpu, Momoko, and Hana join the cast. For the 20th anniversary, the commemorative film “Looking for Magical Doremi” was released in theaters nationwide in November 2020.Magical DoReMi Official Website: https://www.doremi-anniv.com/ Magical DoReMi Official X: @Doremi_staffMagical DoReMi Official Instagram: @doremi_20th_annivMagical DoReMi Official TikTok: @doremi_anniv*When featuring this article, please include the following copyright notices: ©Akiyoshi Hongo, Toei Animation ©Toei AnimationVenue OverviewName:Anime Tokyo Station (also known as "Anime Tokyo")Location:Floors B1 to 2F of Tokyu East 5 (2-25-5 Minami-Ikebukuro, Toshima-ku, Tokyo)*4 minutes on foot from Ikebukuro StationHours:11:00 a.m. to 7:00 p.m. (last admission: 6:45 p.m.)Closed:Mondays *If Monday falls on a holiday, the venue will be open on Monday and closed on the following day New Year's holiday period May be closed on other days Please check the venue website before coming.Admission fee:FreeWebsite:https://animetokyo.jp/en/SNS:X｜https://x.com/animetokyo_info (@animetokyo_info)Instagram｜https://www.instagram.com/animetokyostation/ (@animetokyostation)YouTube｜ https://www.youtube.com/channel/UCSJOjGJE5Yiqw3PZ97AVdJw Inquiries regarding this press releasePublic Relations Office of "Anime Tokyo Station" (Kyodo PR)Contact person: Miri YasudaE-mail: animetokyo-pr@kyodo-pr.co.jp Press release: https://www.acnnewswire.com/docs/files/20251203.pdf Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com

TOKYO, Dec 2, 2025 - (JCN Newswire via SeaPRwire.com) - Eisai Co., Ltd. (Headquarters: Tokyo, CEO: Haruo Naito) today announced that new data on anti-tau antibody etalanetug (development code: E2814) was presented at the 18th Clinical Trials on Alzheimer’s Disease Conference (CTAD). Etalanetug is designed to bind to the microtubule-binding region (MTBR) of tau protein and prevent the seeding and propagation of tau pathology.Anti-tau therapeutic antibody, etalanetug, reduces the novel biomarker plasma eMTBR-tau243 in patients with DIAD (Presentation: December 1, 4:35 PM PT)This presentation is based on the Phase Ib/II study (E2814-103) conducted in individuals (n=7) with dominantly inherited Alzheimer’s disease (DIAD)*. In this study, as previously reported, tau aggregates in the brains of individuals (n=3) were measured using tau PET, and the results showed that the observed tau PET signals were stabilized or trended toward decrease following administration of etalanetug, suggesting that etalanetug inhibited tau propagation and suppressed or reduced the accumulation of tau aggregates in brains.1The study evaluated eMTBR-tau243 as a specific biomarker of tau pathology progression and measured changes in cerebrospinal fluid (CSF) and plasma.MTBR-tau243 is a CSF biomarker correlated with tau pathology, and eMTBR-tau243** has also been developed as a highly sensitive biomarker in plasma.eMTBR-tau243 is a novel fluid biomarker consisting of tau fragments that include tau protein amino acid residue 243 and MTBR, with endogenous cleavage at the C-terminal side of residue 256. It is thought to arise during the formation of neurofibrillary tangles, a key pathological feature of Alzheimer’s disease (AD), and a strong correlation has been shown between tau PET and eMTBR-tau243 in both plasma and CSF.2 By using eMTBR-tau243, it becomes possible to easily measure changes in tau pathology using a blood test.Study results show that etalanetug reduced CSF eMTBR-tau243 by 62% at 3 months and by 89% at 9 months. Similarly, plasma eMTBR-tau243 was reduced by 78% at 3 months and over 90% at 9 months. These findings support etalanetug’s mechanism of action to inhibit tau seeding and spreading in the brain and encourage further studies to determine its clinical potential as a disease-modifying therapy for AD.Currently, etalanetug is being evaluated in two ongoing clinical studies: the Tau NexGen Phase II/III trial in DIAD, conducted under the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) and led by Washington University School of Medicine in St. Louis, added to a standard-of-care anti-Ab protofibril antibody lecanemab (brand name: LEQEMBI), and the Phase II Study 202, a global randomized trial in individuals with early sporadic AD, also assessing etalanetug added to lecanemab as the standard of care.Media Inquiries:Public Relations Department,Eisai Co., Ltd.+81-(0)3-3817-5120Eisai Inc (U.S.)Libby Holman+ 1-201-753-1945Libby_Holman@eisai.com* DIAD: Dominantly Inherited Alzheimer’s disease (DIAD) is a rare form of AD that causes memory loss and dementia in individuals - typically while they are in their 30s to 50s. The disease affects less than 1% of the total population of people with Alzheimer’s disease.** eMTBR-tau243 is a novel fluid biomarker consisting of tau fragments that include tau protein amino acid residue 243 and MTBR, with endogenous cleavage at the C-terminal side of residue 256. It is thought to arise during the formation of neurofibrillary tangles, a key pathological feature of AD, and a strong correlation has been shown between tau PET and eMTBR-tau243 in both plasma and CSF.For more details, please visit: https://www.eisai.com/news/2025/pdf/enews202583pdf.pdf Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com

TOKYO, Dec 2, 2025 - (JCN Newswire via SeaPRwire.com) - NEC Corporation (NEC; TSE: 6701) will begin offering its "NEC AI Agent Service for Procurement Negotiations" in Japan starting this December. This service utilizes NEC's proprietary AI technology, "Automated Negotiation AI," to autonomously generate optimal transaction terms for procurement operations in the manufacturing industry and to negotiate with suppliers.This service automates complex delivery date and quantity adjustment negotiations in manufacturing, drastically reducing the time spent on transaction negotiations. It enables rapid response to demand fluctuations and significantly improves operational efficiency.NEC conducted a proof-of-concept (POC) at an NEC Group company in November 2024, successfully automating delivery date and quantity adjustments with suppliers for the procurement of approximately 1,300 parts.In this proof-of-concept, the "automated agreement rate"—the percentage of agreements reached solely by AI without procurement personnel intervention—reached 95%. Negotiations concluded under optimal conditions for both the supplier and NEC. This confirmed that the adjustment time from negotiation initiation to completion, which previously took several hours to days, could be reduced to just approximately 80 seconds, achieving a significant improvement in operational efficiency.In recent years, negotiations among stakeholders in the manufacturing industry have become increasingly complex due to diversifying demand and the extensive supply chains spanning from raw material procurement to final product delivery. Amid demands for shortening overall supply chain lead times and adapting to high-mix, low-volume production, procurement operations must address risks in a VUCA environment, making efficiency and speed through digital transformation (DX) advancement an urgent priority.However, many companies lack the capacity to swiftly optimize production systems and procurement plans in response to unexpected fluctuations in demand, hindered by factors such as labor shortages, overly personalized work processes, and cost pressures. Particularly, adjusting delivery dates and quantities for parts and raw materials is a critical task directly linked to production planning and potentially leading to lost sales opportunities. Yet, due to its complexity and the time required for negotiations, many items face the challenge of insufficient coordination.NEC developed Automated Negotiation AI to address these challenges, leveraging its proprietary AI technology cultivated through years of research. This technology enables systems to autonomously negotiate with business partners without human intervention, supporting the formation of optimal agreements. This allows for the coordination of procurement timing even for vast numbers of items that were previously unmanageable manually. By curbing excess inventory, preventing stockouts, and avoiding delivery delays, it creates a supply chain resilient to demand fluctuations. Through this service, NEC resolves challenges in increasingly complex supply chains and contributes to enhancing customer competitiveness.Overview of Automated Negotiation AIAutomated Negotiation AI is NEC's proprietary AI technology that adjusts and negotiates on behalf of humans for various coordination tasks traditionally performed by people. It automatically derives essential and desirable conditions for coordination and proposes optimal, mutually acceptable terms. It is designed not only for coordination and negotiation between AI and humans but also for coordination and negotiation between AI systems themselves.Strengths of NEC’s Automated Negotiation AI1. Proprietary Advanced Technology and an Overwhelming Intellectual Property PortfolioNEC's Automated Negotiation AI is proprietary technology enabling optimal agreement formation. It boasts the industry's largest portfolio with 28 related patent applications (as of February 2025).2. Leading Domestic Market Adoption InitiativesNEC is vigorously promoting the automation and adoption of negotiation tasks in Japan through the establishment of the "Autonomous Negotiation SCM Consortium." Beyond merely providing technology, NEC contributes to strengthening the competitiveness of Japanese manufacturing by driving DX across the entire industry.3. Global Trustworthiness Leading International StandardizationNEC's automated negotiation AI technology has been adopted as an international standard for E-Negotiation (*1) by the United Nations' standardization body (UN/CEFACT). It enables smooth collaboration and consensus-building compliant with international standards even in negotiations with international partners, contributing to the optimization of global supply chains.Key Features of This Service1. Automation and Efficiency for Massive Negotiation Workloads Difficult to Handle ManuallyIt automatically detects orders requiring delivery date and quantity adjustments to optimize inventory from all incoming orders and generates negotiation proposals. By presenting these proposals to business partners via AI agents and executing interactive negotiations, it significantly reduces the massive manual adjustment workload.2. Optimization of the Entire Supply Chain and Avoidance of Lost OpportunitiesThe automated negotiation AI calculates optimal negotiation proposals based on transaction data, supporting mutually beneficial agreements. This prevents stockouts and delivery delays, reducing lost sales opportunities. It also helps curb excess inventory, achieving overall supply chain cost optimization while enhancing flexibility and stability.3. Supporting Strategic Procurement OperationsBy automating routine negotiation tasks, procurement personnel can focus on strategic activities such as developing advanced supplier strategies, risk management, and sourcing new suppliers. This contributes to increased productivity and value creation across the entire procurement department.4. Seamless Integration with Existing SystemsIntegration with various existing systems, such as ERP, enables a one-stop procurement process through DX. This allows for smooth implementation and operation while minimizing the burden of system renewal.(*1) https://uncefact.unece.org/spaces/uncefactpublic/pages/65667327/E+NegotiationAbout Automated Negotiation AIhttps://www.nec.com/en/global/solutions/ai/analyze/negotiationai.htmlAbout NECThe NEC Group leverages technology to create social value and promote a more sustainable world where everyone has the chance to reach their full potential. NEC Corporation was established in 1899. Today, the NEC Group’s approximately 110,000 employees utilize world-leading AI, security, and communications technologies to solve the most pressing needs of customers and society. For more information, please visit https://www.nec.com, and follow us on Instagram, Facebook, YouTube, and LinkedIn. Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com